methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate

Base Information

Chemical Name:methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate
CAS No.:1403258-34-3
Molecular Formula:C₁₄H₁₇BrFNO₃
Molecular Weight:346.196
Hs Code.:

Synonyms:methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate

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Chemical Property of methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate

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Technology Process of methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate

There total 4 articles about methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1079992-96-3
(6-fluoro-2-methyl-3-nitrobenzoic acid)

: 1403258-34-3
methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 6 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.1: ammonium chloride; iron / water; methanol / 2.5 h / 70 °C

4.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / 20 °C / Inert atmosphere

4.2: 5.5 h / 20 °C

With sulfuric acid; iron; potassium carbonate; ammonium chloride; acetic acid; In methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 90259-27-1
2-fluoro-6-methylbenzoic acid

: 1403258-34-3
methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; sulfuric acid / 0.75 h / -5 - 0 °C / Cooling with acetone-ice

2.1: sulfuric acid / 6 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4.1: ammonium chloride; iron / water; methanol / 2.5 h / 70 °C

5.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / 20 °C / Inert atmosphere

5.2: 5.5 h / 20 °C

With sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; In methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1403258-31-0
3-bromo-2-fluoro-6-methyl-5-nitrobenzoic acid

: 1403258-34-3
methyl 3-bromo-2-fluoro-6-methyl-5-[(oxan-4-yl)amino]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2.1: ammonium chloride; iron / water; methanol / 2.5 h / 70 °C

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / 20 °C / Inert atmosphere

3.2: 5.5 h / 20 °C

With iron; potassium carbonate; ammonium chloride; acetic acid; In methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;