4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol

Base Information

Chemical Name:4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol
CAS No.:1265774-24-0
Molecular Formula:C₂₉H₂₇FN₂O₃
Molecular Weight:470.543
Hs Code.:

Synonyms:4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol

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Chemical Property of 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol

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Technology Process of 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol

There total 5 articles about 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₈F₄O₄

: 1265774-67-1
ethyl 5-(benzyloxy)-2-(1H-indol-3-yl)pentanoate

: 1265774-24-0
4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol

Guidance literature:: ethyl 5-(benzyloxy)-2-(1H-indol-3-yl)pentanoate; With zinc(II) chloride; In diethyl ether; 1,1-dichloroethane; at 0 ℃; for 0.0833333h; Inert atmosphere;

C₁₁H₈F₄O₄; In diethyl ether; 1,1-dichloroethane; at 0 - 20 ℃; for 1.66667h;

With ammonium acetate; ammonia; In methanol; diethyl ether; 1,1-dichloroethane; at 150 ℃; for 0.5h; sealed tube; microwave irradiation;

Reference yield:

: 778-82-5
ethyl 3-indoleacetate

: 1265774-24-0
4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / dichloromethane / 18 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 1.55 h / 20 - 30 °C

3.1: zinc(II) chloride / 1,1-dichloroethane; diethyl ether / 0.08 h / 0 °C / Inert atmosphere

3.2: 1.67 h / 0 - 20 °C

3.3: 0.5 h / 150 °C / sealed tube; microwave irradiation

With dmap; sodium hydride; triethylamine; zinc(II) chloride; In diethyl ether; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 786647-50-5
tert-butyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate

: 1265774-24-0
4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 1.55 h / 20 - 30 °C

2.1: zinc(II) chloride / 1,1-dichloroethane; diethyl ether / 0.08 h / 0 °C / Inert atmosphere

2.2: 1.67 h / 0 - 20 °C

2.3: 0.5 h / 150 °C / sealed tube; microwave irradiation

With sodium hydride; zinc(II) chloride; In diethyl ether; 1,1-dichloroethane; N,N-dimethyl-formamide; mineral oil;