Technology Process of 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol
There total 5 articles about 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 5-(benzyloxy)-2-(1H-indol-3-yl)pentanoate;
With
zinc(II) chloride;
In
diethyl ether; 1,1-dichloroethane;
at 0 ℃;
for 0.0833333h;
Inert atmosphere;
C11H8F4O4;
In
diethyl ether; 1,1-dichloroethane;
at 0 - 20 ℃;
for 1.66667h;
With
ammonium acetate; ammonia;
In
methanol; diethyl ether; 1,1-dichloroethane;
at 150 ℃;
for 0.5h;
sealed tube;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dmap; triethylamine / dichloromethane / 18 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere
2.2: 1.55 h / 20 - 30 °C
3.1: zinc(II) chloride / 1,1-dichloroethane; diethyl ether / 0.08 h / 0 °C / Inert atmosphere
3.2: 1.67 h / 0 - 20 °C
3.3: 0.5 h / 150 °C / sealed tube; microwave irradiation
With
dmap; sodium hydride; triethylamine; zinc(II) chloride;
In
diethyl ether; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere
1.2: 1.55 h / 20 - 30 °C
2.1: zinc(II) chloride / 1,1-dichloroethane; diethyl ether / 0.08 h / 0 °C / Inert atmosphere
2.2: 1.67 h / 0 - 20 °C
2.3: 0.5 h / 150 °C / sealed tube; microwave irradiation
With
sodium hydride; zinc(II) chloride;
In
diethyl ether; 1,1-dichloroethane; N,N-dimethyl-formamide; mineral oil;
