786647-50-5

Upstream product

• 87-51-4 indole-3-acetic acid 
• 778-82-5 ethyl 3-indoleacetate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1265774-24-0 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol 
• 1265774-29-5 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-yl trifluoromethanesulfonate 
• 1265774-33-1 tert-butyl 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-3-{[(trifluoromethyl)sulfonyl]oxy}-9H-β-carboline-9-carboxylate 
• 1265774-36-4 tert-butyl 3-(benzylamino)-4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carboline-9-carboxylate 
• 1265774-47-7 3-[3-amino-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-4-yl]propan-1-ol 
• 1265773-80-5 6-(3-fluoro-4-methoxybenzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c][1,8]naphthyridine 
• 1265774-76-2 4-(3-chloropropyl)-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-amine 
• 1265773-90-7 2-[6-(3-fluoro-4-methoxybenzyl)-1,2,3,7-tetrahydro-4H-indolo[2,3-c][1,8]naphthyridin-4-yl]acetamide 
• 1265774-67-1 ethyl 5-(benzyloxy)-2-(1H-indol-3-yl)pentanoate 
• 1265774-21-7 tert-butyl 3-[5-(benzyloxy)-1-ethoxy-1-oxopentan-2-yl]-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

Cobalt-Catalyzed C?H Nitration of Indoles by Employing a Removable Directing Group

A mild and efficient C(sp2)?H nitration of 3-substituted indoles, by using the economical and non-toxic cobalt nitrate hexahydrate [Co(NO3)2?6 H2O] as a catalyst and tert-butyl nitrite (TBN) as the nitro source, is reported. This approach provides a unique methodology involving a site-selective C?N bond formation for preparation of C-2 substituted nitro indoles. Utilization of the tBoc as the removable directing group enhances the synthetic utility of the method.

Enantioselective Desymmetrization of 2-Aryl-1,3-propanediols by Direct O-Alkylation with a Rationally Designed Chiral Hemiboronic Acid Catalyst That Mitigates Substrate Conformational Poisoning

Enantioselective desymmetrization by direct monofunctionalization of prochiral diols is a powerful strategy to prepare valuable synthetic intermediates in high optical purity. Boron acids can activate diols toward nucleophilic additions; however, the design of stable chiral catalysts remains a challenge and highlights the need to identify new chemotypes for this purpose. Herein, the discovery and optimization of a bench-stable chiral 9-hydroxy-9,10-boroxarophenanthrene catalyst is described and applied in the highly enantioselective desymmetrization of 2-aryl-1,3-diols using benzylic electrophiles under operationally simple, ambient conditions. Nucleophilic activation and discrimination of the enantiotopic hydroxy groups on the diol substrate occurs via a defined chairlike six-membered anionic complex with the hemiboronic heterocycle. The optimal binaphthyl-based catalyst 1g features a large aryloxytrityl group to effectively shield one of the two prochiral hydroxy groups on the diol complex, whereas a strategically placed "methyl blocker"on the boroxarophenanthrene unit mitigates the deleterious effect of a competing conformation of the complexed diol that compromised the overall efficiency of the desymmetrization process. This methodology affords monoalkylated products in enantiomeric ratios equal or over 95:5 for a wide range of 1,3-propanediols with various 2-aryl/heteroaryl groups.

BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS

The present invention pertains to Benzyl-substituted tetracyclic heterocyclic compounds, as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases.

Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis: Asymmetric entry to the spiro-β-lactam core of chartellines

A versatile, highly enantiocontrolled entry to the spiro-β-lactam core of chartellines has been developed by expanding the scope of oxidative nitrogen atom transfer methodology based on chiral Rh-nitrenoid species.

HYDROXAMIC ACIDS USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.