Technology Process of C21H25N3O3
There total 6 articles about C21H25N3O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(3,5-dimethylphenylamino)-2-oxoacetic acid;
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
Molecular sieve;
(S)-(1-(2-aminophenyl)pyrrolidin-2-yl)methanol;
In
tetrahydrofuran; dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
Molecular sieve;
DOI:10.1016/j.tetasy.2011.11.015
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide / tetrahydrofuran; water
1.2: Acidic conditions
2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere; Molecular sieve
2.2: 0 - 20 °C / Inert atmosphere; Molecular sieve
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetasy.2011.11.015
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / 1.5 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran; water
2.2: Acidic conditions
3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere; Molecular sieve
3.2: 0 - 20 °C / Inert atmosphere; Molecular sieve
With
pyridine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetasy.2011.11.015
