[(3,5-dimethylphenyl)amino](oxo)acetic acid

Base Information

• Chemical Name: [(3,5-dimethylphenyl)amino](oxo)acetic acid
• CAS No.: 1018295-15-2
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.202
• Mol file: 1018295-15-2.mol

Synonyms:2-(3,5-dimethylphenylamino)-2-oxoacetic acid

Chemical Property of [(3,5-dimethylphenyl)amino](oxo)acetic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

[(3,5-Dimethylphenyl)amino](oxo)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3,5-dimethylphenyl)amino](oxo)acetic acid

There total 2 articles about [(3,5-dimethylphenyl)amino](oxo)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,5-dimethylphenylamino)-2-oxoacetic acidethyl ester (333441-77-3) → 2-(3,5-dimethylphenylamino)-2-oxoacetic acid (1018295-15-2)

Guidance literature:

2-(3,5-dimethylphenylamino)-2-oxoacetic acidethyl ester; With sodium hydroxide; In tetrahydrofuran; water;

In tetrahydrofuran; water; Acidic conditions;

DOI:10.1016/j.tetasy.2011.11.015

Reference yield:

3,5-dimethylaminoaniline (108-69-0) → 2-(3,5-dimethylphenylamino)-2-oxoacetic acid (1018295-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / 1.5 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water

2.2: Acidic conditions

With pyridine; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.tetasy.2011.11.015

Reference yield: 50.0%

2-(3,5-dimethylphenylamino)-2-oxoacetic acid (1018295-15-2) + (S)-2-(2-(methoxymethyl)pyrrolidin-1-yl)aniline (1358742-07-0) → C22H27N3O3 (1358742-28-5)

Guidance literature:

2-(3,5-dimethylphenylamino)-2-oxoacetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 0 ℃; for 1h; Inert atmosphere; Molecular sieve;

(S)-2-(2-(methoxymethyl)pyrrolidin-1-yl)aniline; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.tetasy.2011.11.015

upstream raw materials:

2-(3,5-dimethylphenylamino)-2-oxoacetic acidethyl ester

3,5-dimethylaminoaniline

Downstream raw materials:

C₂₁H₂₅N₃O₃

C₂₂H₂₇N₃O₃

(S)-N₁-(2-(2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)phenyl)-N₂-(3,5-dimethylphenyl)oxalamide

(S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol