tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

Base Information

Chemical Name:tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester
CAS No.:318988-53-3
Molecular Formula:C₂₅H₂₉N₃O₄
Molecular Weight:435.523
Hs Code.:

Synonyms:tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

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Chemical Property of tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

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Technology Process of tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

There total 6 articles about tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ({2-[(E)-1-Benzyl-4-hydroxy-piperidin-4-ylmethylimino]-ethyl}-benzyloxycarbonyl-amino)-acetic acid

: 318988-53-3
tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1248/cpb.54.1535

Reference yield:

: 2-[[(3,8-diaza-8-benzyl-1-oxaspiro[4.5]decan-2-yl)methyl](benzyloxycarbonyl)amino]acetic acid

: 318988-53-3
tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

: 318988-51-1
N-(2-oxoethyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester

: 318988-53-3
tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 1 h / Heating

2: aq. LiOH / methanol / 1 h / 20 °C

3: 86 g / N'-(ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine*HCl / CH₂Cl₂ / 20 °C

With lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; toluene;
DOI:10.1248/cpb.54.1535