1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one

Base Information

Chemical Name:1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one
CAS No.:318988-54-4
Molecular Formula:C₁₈H₂₃N₃O₄
Molecular Weight:345.398
Hs Code.:

Synonyms:1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one

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Chemical Property of 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one

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Technology Process of 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one

There total 7 articles about 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 318988-53-3
tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester

: 318988-54-4
1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one

Guidance literature:: tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester; With carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

In methanol; for 1h; Heating;
DOI:10.1248/cpb.54.1535

Reference yield:

: 318988-51-1
N-(2-oxoethyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester

: 318988-54-4
1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 1 h / Heating

2.1: aq. LiOH / methanol / 1 h / 20 °C

3.1: 86 g / N'-(ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine*HCl / CH₂Cl₂ / 20 °C

4.1: 1,8-bis(dimethylamino)naphthalene; α-chloroethyl chloroformate / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 68 percent / methanol / 1 h / Heating

With lithium hydroxide; carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1248/cpb.54.1535

Reference yield:

: ({2-[(E)-1-Benzyl-4-hydroxy-piperidin-4-ylmethylimino]-ethyl}-benzyloxycarbonyl-amino)-acetic acid

: 318988-54-4
1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 g / N'-(ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine*HCl / CH₂Cl₂ / 20 °C

2.1: 1,8-bis(dimethylamino)naphthalene; α-chloroethyl chloroformate / 1,2-dichloro-ethane / 1 h / 20 °C

2.2: 68 percent / methanol / 1 h / Heating

With carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1248/cpb.54.1535