(S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

Base Information

Chemical Name:(S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline
CAS No.:1215022-30-2
Molecular Formula:C₂₂H₂₇ClN₂OSi
Molecular Weight:399.008
Hs Code.:

Synonyms:(S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

Suppliers and Price of (S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

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Technology Process of (S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

There total 3 articles about (S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1215022-25-5
(S)-2-(1-(tert-butyldimethylsilyloxy)-2-phenylethyl)quinazolin-4(3H)-one

: 1215022-30-2
(S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

Guidance literature:: With N,N-diethylaniline; trichlorophosphate; In benzene; Reflux;
DOI:10.1016/j.tetasy.2009.12.002

Reference yield:

: 1215022-20-0
(S)-2-(1-hydroxy-2-phenylethyl)quinazolin-4(3H)-one

: 1215022-30-2
(S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / Reflux

2: trichlorophosphate; N,N-diethylaniline / benzene / 4 h / Reflux

With 1H-imidazole; N,N-diethylaniline; trichlorophosphate; In N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-0035-1561584

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1215022-30-2
(S)-2-{1-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl}-4-chloroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / Reflux

2: trichlorophosphate; N,N-diethylaniline / benzene / 4 h / Reflux

With 1H-imidazole; N,N-diethylaniline; trichlorophosphate; In N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-0035-1561584