4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Base Information

Chemical Name:4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide
CAS No.:1369762-34-4
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Suppliers and Price of 4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

There total 6 articles about 4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 1369762-29-7
4-(2,4-dimethoxybenzyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

: 1369762-34-4
4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In toluene; at 110 ℃; for 18h; Sealed tube; Inert atmosphere;
DOI:10.1021/ol300468g

Reference yield: 13.0%

: 696-62-8
para-iodoanisole

: 1369762-29-7
4-(2,4-dimethoxybenzyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

: 1369762-34-4
4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In toluene; at 110 ℃; for 18h; Sealed tube; Inert atmosphere;
DOI:10.1021/ol300468g

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1369762-34-4
4-(2,4-dimethoxybenzyl)-2-(4-methoxyphenyl)-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide

Guidance literature:: Multi-step reaction with 5 steps

1: propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

3: triethylamine / ethanol / 16 h / 100 °C / Molecular sieve

4: 3-chloro-benzenecarboperoxoic acid / 3 h / 0 °C

5: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 18 h / 110 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; propylphosphonic anhydride; palladium diacetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/ol300468g