3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin

Base Information

• Chemical Name: 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin
• CAS No.: 1252258-49-3
• Molecular Formula: C₅₆H₇₈O₈
• Molecular Weight: 879.231
• Mol file: 1252258-49-3.mol

Synonyms:3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin

Chemical Property of 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin

There total 1 articles about 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,3-dimethylglutaric anhydride (4160-82-1) + 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester (1252258-40-4) → 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin (1252258-49-3)

Guidance literature:

3,3-dimethylglutaric anhydride; 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester; With pyridine; dmap; Reflux;

With water; Cooling with ice;

DOI:10.1016/j.bmc.2010.06.092

Reference yield: 74.2%

3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin (1252258-49-3) + 3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) → 3'-azido-3'-deoxythymidin-5'-yl 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-lup-2'(29)en-28-yl 3,3-dimethylglutarate (1252258-63-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2010.06.092

upstream raw materials:

3,3-dimethylglutaric anhydride

3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester

Downstream raw materials:

3'-azido-3'-deoxythymidin-5'-yl 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-lup-2'⁽²⁹⁾en-28-yl 3,3-dimethylglutarate