3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester

Base Information

• Chemical Name: 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester
• CAS No.: 1252258-40-4
• Molecular Formula: C₄₉H₆₈O₅
• Molecular Weight: 737.076
• Mol file: 1252258-40-4.mol

Synonyms:3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester

Chemical Property of 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester

There total 1 articles about 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazodiphenylmethane (908093-98-1) + 2,2-Dimethyl-succinic acid 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-hydroxymethyl-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysen-9-yl) ester (677350-29-7) → 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester (1252258-40-4)

Guidance literature:

In methanol; dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2010.06.092

Reference yield: 87.0%

3,3-dimethylglutaric anhydride (4160-82-1) + 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester (1252258-40-4) → 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin (1252258-49-3)

Guidance literature:

3,3-dimethylglutaric anhydride; 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester; With pyridine; dmap; Reflux;

With water; Cooling with ice;

DOI:10.1016/j.bmc.2010.06.092

Reference yield: 76.8%

succinic acid anhydride (108-30-5) + 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester (1252258-40-4) → 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-succinylbetulin (1252258-45-9)

Guidance literature:

succinic acid anhydride; 3-O-(3',3'-dimethylsuccinyl)betulin benzhydryl ester; With pyridine; dmap; Reflux;

With water; Cooling with ice;

DOI:10.1016/j.bmc.2010.06.092

upstream raw materials:

diazodiphenylmethane

2,2-Dimethyl-succinic acid 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-hydroxymethyl-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysen-9-yl) ester

Downstream raw materials:

3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-succinylbetulin

3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-glutarylbetulin

3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)betulin

3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylsuccinyl)betulin