Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester

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Chemical Name:Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester
CAS No.:849799-26-4
Molecular Formula:C₂₅H₂₅F₂NO₄S
Molecular Weight:473.541
Hs Code.:

Synonyms:Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester

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Chemical Property of Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester

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Technology Process of Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester

There total 6 articles about Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 849799-25-3
Methanesulfonic acid 4-[(2S,3S)-3-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-azetidin-2-yl]-phenyl ester

: 849799-26-4
Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃; for 8h;
DOI:10.1021/jm050422p

Reference yield:

: 795306-57-9
3′-(S)-4-(S)-3-(R)-[3′-t-butyldimethylsilyloxy-3′-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-1-(4-fluorophenyl)azetidin-2-one

: 849799-26-4
Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / pyridine / CH₂Cl₂ / 22 h

2: 77 percent / LiAlH₄; AlCl₃ / diethyl ether / 0.25 h / 0 °C

3: 85 percent / HF*pyridine / tetrahydrofuran / 8 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; pyridine hydrogenfluoride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm050422p

Reference yield:

: 795306-53-5
Acetic acid 4-{(2S,3R)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-oxo-azetidin-2-yl}-phenyl ester

: 849799-26-4
Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / imidazole / dimethylformamide / 3 h

2: 83 percent / Al₂O₃ / 5.5 h / 70 °C

3: 92 percent / pyridine / CH₂Cl₂ / 22 h

4: 77 percent / LiAlH₄; AlCl₃ / diethyl ether / 0.25 h / 0 °C

5: 85 percent / HF*pyridine / tetrahydrofuran / 8 h / 0 - 20 °C

With pyridine; 1H-imidazole; aluminum oxide; lithium aluminium tetrahydride; aluminium trichloride; pyridine hydrogenfluoride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050422p