exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

Base Information

Chemical Name:exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid
CAS No.:939789-45-4
Molecular Formula:C₁₉H₂₅BN₂O₅
Molecular Weight:372.229
Hs Code.:

Synonyms:exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

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Chemical Property of exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

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Technology Process of exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

There total 2 articles about exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 945565-37-7
exo tert-butyl 3-(3-bromo-5-cyanophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 939789-45-4
exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

Guidance literature:: exo tert-butyl 3-(3-bromo-5-cyanophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3.08333h;

With hydrogenchloride; In tetrahydrofuran; hexane; water;

Reference yield:

: C₂₅H₃₇BN₂O₅

: 939789-45-4
exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

Guidance literature:: With hydrogenchloride; In water;
DOI:10.1016/j.bmcl.2010.11.021

Reference yield: 92.0%

: 17282-04-1
2-chloro-3-fluoropyridine

: 939789-45-4
exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

: 939789-46-5
exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate

Guidance literature:: With potassium phosphate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 0.166667h; Microwave;