exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate

Base Information

Chemical Name:exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate
CAS No.:939789-46-5
Molecular Formula:C₂₄H₂₆FN₃O₃
Molecular Weight:423.487
Hs Code.:

Synonyms:exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate

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Chemical Property of exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate

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Technology Process of exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate

There total 1 articles about exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 17282-04-1
2-chloro-3-fluoropyridine

: 939789-45-4
exo 3-[8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]oct-3-yloxy]-5-cyanophenylboronic acid

: 939789-46-5
exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate

Guidance literature:: With potassium phosphate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 0.166667h; Microwave;

Reference yield: 58.0%

: 939789-46-5
exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate

: 3-(8-azabicyclo[3.2.1]oct-3-yloxy)-5-(3-fluoropyridin-2-yl)benzonitrile

Guidance literature:: exo tert-butyl 3-[3-cyano-5-(3-fluoropyridin-2-yl)phenoxy]-8-azabicyclo[3.2.1]octe-8-carboxylate; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonia; In methanol;