trans-2-ethynylstilbene

Base Information

• Chemical Name: trans-2-ethynylstilbene
• CAS No.: 81462-47-7
• Molecular Formula: C₁₆H₁₂
• Molecular Weight: 204.271
• Mol file: 81462-47-7.mol

Synonyms:trans-2-ethynylstilbene

Chemical Property of trans-2-ethynylstilbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of trans-2-ethynylstilbene

There total 21 articles about trans-2-ethynylstilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

1-[(E)-2-(phenyl)ethenyl]-2-[2-(trimethylsilyl)ethynyl]benzene → (E)-1-ethynyl-2-(β-styryl)benzene (81462-47-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 27 ℃; for 10h;

DOI:10.1021/ja0379159

Reference yield: 85.0%

1-iodo-2-[(E)-2-phenylethenyl]benzene (5025-41-2,1138-43-8,92106-62-2) + trimethylsilylacetylene (1066-54-2) → (E)-1-ethynyl-2-(β-styryl)benzene (81462-47-7)

Guidance literature:

1-iodo-2-[(E)-2-phenylethenyl]benzene; trimethylsilylacetylene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In 1,4-dioxane; at 45 ℃; Inert atmosphere;

With potassium fluoride; In methanol; at 25 ℃; for 3h;

DOI:10.1016/j.bmcl.2016.07.031

Reference yield:

2-[2-(trimethylsilyl)ethynyl]benzaldehyde (77123-58-1) → (E)-1-ethynyl-2-(β-styryl)benzene (81462-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / NaH / tetrahydrofuran / 12 h / 26 °C

2: 85.6 percent / Bu₄NF / tetrahydrofuran / 10 h / 27 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;

DOI:10.1021/ja0379159

upstream raw materials:

2-(α-chlorovinyl)stilbene

2-(β-chlorovinyl)stilbene

2-(2-chlorovinyl)stilbene

1-formyl-2-(2-phenylethenyl)-benzene

Downstream raw materials:

2-phenylnaphthalene

phenanthrenylacetylene

exo-3,4-Benzo-6-phenylbicyclo[3.1.0]hex-3-en-2-on

(E)-3-(2-benzyl-6,7-dimethoxy-4-(2-phenyl-1H-inden-1-ylidene)-1,2,3,4-tetrahydroisoquinolin-3-yl)-9-ethyl-9H-carbazole