6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine

Base Information

• Chemical Name: 6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine
• CAS No.: 1015763-73-1
• Molecular Formula: C₁₂H₁₃N₃O₂S
• Molecular Weight: 263.32
• Mol file: 1015763-73-1.mol

Synonyms:6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine

Chemical Property of 6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine

There total 1 articles about 6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-((4-methoxyphenyl)amino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (1015763-68-4) + methyl iodide (74-88-4) → 6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine (1015763-73-1)

Guidance literature:

With potassium hydroxide; at 0 - 5 ℃; for 0.5h;

DOI:10.1016/j.bmc.2007.10.014

Reference yield:

6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine (1015763-73-1) → 7-methoxy-2-((1-phenylethyl)amino)benzo[g]pteridin-4(3H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite / 20 °C

2: N,N-dimethyl-formamide / Reflux

With sodium nitrite; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.04.029

Reference yield:

6-(4-methoxyanilino)-2-methylthio-4-oxo-3,4-dihydropyrimidine (1015763-73-1) → 7-methoxy-2-((4-((4-methylpiperazin-1-yl)methyl)benzyl)amino)benzo[g]pteridin-4(3H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite / 20 °C

2: N,N-dimethyl-formamide / Reflux

With sodium nitrite; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.04.029

upstream raw materials:

6-((4-methoxyphenyl)amino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

methyl iodide