ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate

Base Information

• Chemical Name: ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate
• CAS No.: 147101-70-0
• Molecular Formula: C₁₇H₂₀N₂O₅S
• Molecular Weight: 364.422
• Mol file: 147101-70-0.mol

Synonyms:ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate

Chemical Property of ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate

There total 1 articles about ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,4-Dimethoxybenzylamine (20781-20-8) + ethyl (4-methoxycarbonyl)thiophene-3-carbamate (118252-16-7) → ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate (147101-70-0)

Guidance literature:

With trimethylaluminum; In toluene; for 72h; Ambient temperature;

DOI:10.1080/00397919208021136

Reference yield: 95.0%

ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate (147101-70-0) → 3-(2,4-dimethoxyphenylmethyl)thieno<3,4-d>pyrimidine-2,4-dione (147101-71-1)

Guidance literature:

With sodium hydroxide; In methanol; at 50 ℃; for 5h;

DOI:10.1080/00397919208021136

Reference yield:

ethyl <4-<<(2,4-dimethoxyphenylmethyl)amino>carbonyl>thiophen-3-yl>carbonate (147101-70-0) → 1-(2-chloroethyl)-3-(2,4-dimethoxyphenylmethyl)thieno<3,4-d>pyrimidine-2,4-dione (147101-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 12.5N aq. NaOH / methanol / 5 h / 50 °C

2: 100 percent / NaH / dimethylsulfoxide / 4.5 h / 30 °C

With sodium hydroxide; sodium hydride; In methanol; dimethyl sulfoxide;

DOI:10.1080/00397919208021136

upstream raw materials:

2,4-Dimethoxybenzylamine

ethyl (4-methoxycarbonyl)thiophene-3-carbamate

Downstream raw materials:

3-(2,4-dimethoxyphenylmethyl)thieno<3,4-d>pyrimidine-2,4-dione

1-(2-chloroethyl)-3-(2,4-dimethoxyphenylmethyl)thieno<3,4-d>pyrimidine-2,4-dione

1-<2-<4-(4-fluorobenzoyl)piperidin-1-yl>ethyl>-3-(2,4-dimethoxyphenylmethyl)thieno<3,4-d>pyrimidine-2,4-dione

3-(2,4-dimethoxyphenylmethyl)-1-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione