Technology Process of 3-chloro-4-{[1-(5-phenylpentyl)-1H-indol-5-yl]oxy}benzonitrile
There total 3 articles about 3-chloro-4-{[1-(5-phenylpentyl)-1H-indol-5-yl]oxy}benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-chloro-4-(1H-indol-5-yloxy)benzonitrile;
With
potassium hydroxide;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.666667h;
(5-bromopentyl)benzene;
In
dimethyl sulfoxide;
at 20 ℃;
for 2h;
DOI:10.1248/cpb.48.382
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonium formate / 10 percent Pd/C / ethanol / 3 h / 20 °C
2.1: K2CO3 / dimethylformamide / 16 h / 80 °C
3.1: KOH / dimethylsulfoxide / 0.67 h / 20 °C
3.2: 62 percent / dimethylsulfoxide / 2 h / 20 °C
With
potassium hydroxide; ammonium formate; potassium carbonate;
palladium on activated charcoal;
In
ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: Hydrogenolysis / 2.1: Substitution / 3.1: deprotonation / 3.2: Alkylation;
DOI:10.1248/cpb.48.382
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: K2CO3 / dimethylformamide / 16 h / 80 °C
2.1: KOH / dimethylsulfoxide / 0.67 h / 20 °C
2.2: 62 percent / dimethylsulfoxide / 2 h / 20 °C
With
potassium hydroxide; potassium carbonate;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: Substitution / 2.1: deprotonation / 2.2: Alkylation;
DOI:10.1248/cpb.48.382
