14469-83-1

Basic information

• Product Name: 1-BROMO-5-PHENYLPENTANE
• Synonyms: RARECHEM AH CK 0049;(5-BROMOPENTYL)BENZENE;(5-BROMO-N-PENTYL)BENZENE;5-PHENYLPENTYL BROMIDE;1-BROMO-5-PHENYLPENTANE;1-Bromo-5-phenylpentane 95+%;1-BROMO-5-PHENYL-PENTANE >97%;1-BROMO-5-CHLOROPENTANE
• CAS NO: 14469-83-1
• Molecular Formula: C₁₁H₁₅Br
• Molecular Weight: 227.14
• Mol File: 14469-83-1.mol

Chemical Properties

• Boiling Point: 148 °C / 18mmHg
• Flash Point: 150.5 °C
• Appearance: Clear colorless/Liquid
• Density: 1,23 g/cm3
• Vapor Pressure: 0.00579mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: 1-BROMO-5-PHENYLPENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-5-PHENYLPENTANE(14469-83-1)
• EPA Substance Registry System: 1-BROMO-5-PHENYLPENTANE(14469-83-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37/39
• Hazardous Substances Data: 14469-83-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C11H15Br/c12-10-6-2-5-9-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2

Upstream product

• 10521-91-2 5-phenylpentan-1-ol 
• 111-24-0 1,5-dibromo-pentane 
• 100-47-0 benzonitrile 
• 17920-83-1 5-phenyl-4-pentenoic acid 
• 37464-85-0 methyl 5-phenylpent-4-enoate 
• 13159-16-5 5-phenyl-4-penten-1-ol 
• 100-52-7 benzaldehyde 
• 20620-59-1 5-phenyl-n-valeric acid methyl ester 
• 17734-38-2 ethyl 5-phenylpentanoate 
• 16002-93-0 (E)-1-phenyl-1-pentene 
• 108-55-4 glutaric anhydride, 
• 71-43-2 benzene 
• 20371-41-9 5-phenylvaleric acid chloride 
• 637-59-2 1-Bromo-3-phenylpropane 

Downstream Products

• 102010-09-3 acetic acid-[4-(5-phenyl-pentyloxy)-anilide] 
• 100129-15-5 1-(5-bromo-pentyl)-4-nitro-benzene 
• 854848-15-0 bis-(5-phenyl-pentyl)-disulfide 
• 101879-28-1 [5-(2,4-dinitro-phenyl)-pentyl]-(4-nitro-phenyl)-ether 
• 7322-12-5 trimethyl-(5-phenyl-pentyl)-ammonium; bromide 
• 33856-86-9 2-Ethyl-7-phenyl-heptanal 
• 70860-01-4 C₂₀H₂₆N₂O₃ 
• 14401-85-5 C₂₄H₃₀ 
• 56293-02-8 7-phenylhept-1-yne 
• 17777-31-0 6-phenylhexanenitrile 
• 108984-51-6 1-<2,6-Dimethoxy-4-nitro-phenoxy>-5-phenyl-pentan 
• 94067-96-6 N-<5-(4-Nitro-phenyl)-pentyl>-benzamid 
• 35008-87-8 oct-7-en-1-ylbenzene 
• 81631-40-5 1-phenyl-5-trimethylsilyl-pentan 

Relevant articles and documents

NaBH4 in N-methylpyrrolidone: a safe alternative for hydride displacement reaction.

Enhanced reactivity of NaBH4 was observed as a solution in N-methylpyrrolidone (NMP). Thus, a simple protocol for debromination of alkyl bromide and sulfonate is devised with NMP as a key solvent. Also described is a new mixed borohydride system, NaBH4-LiOTf-NMP, which works as an alternative to NaBH3CN for the SN2 type displacement. No reports have ever revealed usefulness of NMP in borohydride reduction.

Self-assembling properties of non-ionic tetraphenylporphyrins and discotic phthalocyanines carrying oligo(ethylene oxide) alkyl or alkoxy units

The thermotropic phase behaviour and self-assembling features of some non-ionic tetraphenylporphyrins and phthalocyanines containing oligo(ethylene oxide) alkoxy or alkyl units have been investigated. From DSC measurements and polarization microscopy it was concluded that none of the tetraphenylporphyrins was mesomorphic while the phthalocyanines displayed discotic hexagonal phases even at room temperature. The aggregation of the compounds in aqueous media was studied by means of UV-VIS and fluorescence spectroscopy and it has been found that in water the tetraphenylporphyrins form J- or head-to-tail type of aggregates while phthalocyanines form H- or face-to-face type of aggregates. The luminescence properties of the tetraphenylporphyrin and phthalocyanine aggregates are explained on the basis of the molecular exciton approximation. Steric constraints and orientational disorder in the tetraphenylporphyrin aggregates determine the luminescence yield relative to the monomeric species. The cofacial arrangement of the macrocycles in phthalocyanine aggregates results in a forbidden S1-S0 transition and thus in a complete disappearance of the luminescence.

IRIDIUM COMPLEX COMPOUND, COMPOSITION CONTAINING THE COMPOUND, ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE AND ILLUMINATION DEVICE

PROBLEM TO BE SOLVED: To provide an iridium complex compound showing high quantum yield or the like, which is particularly useful for an organic electroluminescent element. SOLUTION: The present invention provides an iridium complex compound represented by formula (1) [R1-R3 are an SF5 group, H, an alkyl group or the like; at least one of R1-R3 is an SF5 group or an alkyl group containing SF5 group; ring A is a 5 membered/6 membered heteroaromatic ring containing N and C; m is an integer of 1-3; n1-n3 are an integer of 0-4]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Substrate and Catalyst Effects in the Enantioselective Copper-Catalysed C–H Insertion Reactions of α-Diazo-β-oxo Sulfones

Excellent enantioselectivities of up to 98 % ee are achieved by employing the copper-bis(oxazoline)-NaBARF catalyst system in the C–H insertion reactions of α-diazo-β-oxo sulfones. The influence of variation of the bis(oxazoline) ligand, copper salt, additive and substrate on both the efficiency and the enantioselectivities of these intramolecular C–H insertion reactions has been explored. Optimum enantioselectivities are achieved with phenyl and diphenyl ligands across the substrate series.

Bent-core mesogens with an aromatic unit at the terminal position

Bent-core liquid crystals with a naphthalene central unit and an aromatic ring at the terminal position of molecular tails were synthesised with the aim of enhancing nanosegregation. It was found that the length of the spacer between the rigid core and the terminal aromatic moiety had a profound influence on the liquid crystal polymorphism. The homologues with short spacers exhibited nematic and columnar phases, whereas the homologue with long spacers exhibited a tilted lamellar phase with a liquid-like in-plane order, indicating an unusual morphology of the densely packed toroidal objects. The morphology can be changed to twisted ribbons by small additives adsorbed on the membrane surface. This is the first example of twisted ribbons constructed by a lamellar system with no long-range in-plane order.

Redox-Active Esters in Fe-Catalyzed C-C Coupling

Cross-couplings of alkyl halides and organometallic species based on single electron transfer using Ni and Fe catalyst systems have been studied extensively, and separately, for decades. Here we demonstrate the first couplings of redox-active esters (both isolated and derived in situ from carboxylic acids) with organozinc and organomagnesium species using an Fe-based catalyst system originally developed for alkyl halides. This work is placed in context by showing a direct comparison with a Ni catalyst for >40 examples spanning a range of primary, secondary, and tertiary substrates. This new C-C coupling is scalable and sustainable, and it exhibits a number of clear advantages in several cases over its Ni-based counterpart.

Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using

Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693

14-3-3 is a family of highly conserved adapter proteins that is attracting much interest among medicinal chemists. Small-molecule inhibitors of 14-3-3 protein-protein interactions (PPIs) are in high demand, both as tools to increase our understanding of 14-3-3 actions in human diseases and as leads to develop innovative therapeutic agents. Herein we present the discovery of novel 14-3-3 PPI inhibitors through a multidisciplinary strategy combining molecular modeling, organic synthesis, image-based high-content analysis of reporter cells, and in vitro assays using cancer cells. Notably, the two most active compounds promoted the translocation of c-Abl and FOXO pro-apoptotic factors into the nucleus and sensitized multidrug-resistant cancer cells to apoptotic inducers such as doxorubicin and the pan-Akt inhibitor GSK690693, thus becoming valuable lead candidates for further optimization. Our results emphasize the possible role of 14-3-3 PPI inhibitors in anticancer combination therapies. Pièce de résistance! Multidrug resistance (MDR) is the main obstacle toward effective anticancer therapy. Herein we report the discovery of two small-molecule 14-3-3 protein-protein interaction inhibitors that promote the translocation of c-Abl and FOXO pro-apoptotic factors into the nucleus and sensitize MDR cancer cells to doxorubicin and the pan-Akt inhibitor GSK690693.

Non-imidazole histamine H3 ligands: Part V. synthesis and preliminary pharmacological investigation of 1-[2-thiazol-4-yl- and 1-[2-thiazol-5-yl-(2-aminoethyl)]-4-n-propylpiperazine derivatives

Series of 1-[2-thiazol-4-yl-(2-aminoethyl)]- and 1-[2-thiazol-5-yl-(2- aminoethyl)]-4-n-propylpiperazine derivatives have been prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunu

Halogenation of primary alcohols using a tetraethylammonium halide/[Et 2NSF2]BF4 combination

The halogenation of primary alcohols is presented. The use of a combination of tetraethylammonium halide and [Et2NSF2]BF4 (XtalFluor-E) allows for chlorination and bromination reactions to proceed efficiently (up to 92% yield) with a wide range of alcohols. Iodination reactions are also possible albeit in lower yields.