[3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one

Base Information

Chemical Name:[3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one
CAS No.:1026302-61-3
Molecular Formula:C₃₁H₃₁F₃N₂O₆
Molecular Weight:584.592
Hs Code.:

Synonyms:[3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one

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Chemical Property of [3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one

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Technology Process of [3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one

There total 8 articles about [3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84923-70-6
5-formyl-2-methoxybenzoic acid

: 1026302-61-3
[3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: KHCO₃ / dimethylformamide / 4 h / 20 °C

2.1: NaH / tetrahydrofuran / 1 h

2.2: 74 percent / tetrahydrofuran / 4.5 h / 20 °C

3.1: 98 percent / H₂ / Pd/C / ethanol / 3 h / 2647.71 Torr

4.1: Et₃N / CH₂Cl₂ / 0.17 h / -10 °C

5.1: 7.20 g / CH₂Cl₂ / -10 - 20 °C

6.1: 95 percent / aq. NaOH / ethanol / 4 h / 50 °C

7.1: Et₃N / tetrahydrofuran / 1.5 h / 20 °C

8.1: KOtBu / tetrahydrofuran / 0.75 h

8.2: tetrahydrofuran

With sodium hydroxide; potassium tert-butylate; hydrogen; sodium hydride; potassium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205144

Reference yield:

: 311770-86-2
benzyl 5-formyl-2-methoxybenzoate

: 1026302-61-3
[3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran / 1 h

1.2: 74 percent / tetrahydrofuran / 4.5 h / 20 °C

2.1: 98 percent / H₂ / Pd/C / ethanol / 3 h / 2647.71 Torr

3.1: Et₃N / CH₂Cl₂ / 0.17 h / -10 °C

4.1: 7.20 g / CH₂Cl₂ / -10 - 20 °C

5.1: 95 percent / aq. NaOH / ethanol / 4 h / 50 °C

6.1: Et₃N / tetrahydrofuran / 1.5 h / 20 °C

7.1: KOtBu / tetrahydrofuran / 0.75 h

7.2: tetrahydrofuran

With sodium hydroxide; potassium tert-butylate; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm0205144

Reference yield:

: 311770-43-1
ethyl (3-benzyloxycarbonyl-4-methoxyphenyl)-2-ethylacrylate

: 1026302-61-3
[3(2R),4S]-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propionyl]-4-benzyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / H₂ / Pd/C / ethanol / 3 h / 2647.71 Torr

2.1: Et₃N / CH₂Cl₂ / 0.17 h / -10 °C

3.1: 7.20 g / CH₂Cl₂ / -10 - 20 °C

4.1: 95 percent / aq. NaOH / ethanol / 4 h / 50 °C

5.1: Et₃N / tetrahydrofuran / 1.5 h / 20 °C

6.1: KOtBu / tetrahydrofuran / 0.75 h

6.2: tetrahydrofuran

With sodium hydroxide; potassium tert-butylate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm0205144