84923-70-6Relevant academic research and scientific papers
OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY
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Page/Page column 109, (2015/01/07)
The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Synthesis of aromatic carboxylic acids by carbonylation of aryl halides in the presence of epoxide-modified cobalt carbonyls as catalysts
Boyarskii,Zhesko,Lanina
, p. 1844 - 1848 (2007/10/03)
A new procedure was developed for synthesis of aromatic and heteroaromatic acids and their derivatives (esters, salts) by carbonylation of the corresponding aryl halides. The acids are selectively formed in a high yield under very mild conditions. Highly active catalytic systems, base-containing alcoholic solutions of cobalt carbonyl modified with epoxides, were used to activate aryl halides. 2005 Pleiades Publishing, Inc.
Thiazolidine derivatives and its use as antifungal agent
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, (2008/06/13)
Compounds of formula (I) or salts thereof are provided wherein X is O or S, A and B are OR2 or Y—NR3R4 wherein when A is OR2. B is Y—NR3R4 and vice versa, or when one of A or B is OR2. then the other can be CO2R7. Y is CH2 or C=Q. Q is (CH2)m—CH(R1)—(CH2)n, R is OR6 or NHR7. and with the other definitions as set out in claim 1, a process for its preparation and its use in the prophylaxis or treatment of fungal infections. 1
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: Novel human PPARα-selective activators
Miyachi, Hiroyuki,Nomura, Masahiro,Tanase, Takahiro,Takahashi, Yukie,Ide, Tomohiro,Tsunoda, Masaki,Murakami, Koji,Awano, Katsuya
, p. 77 - 80 (2007/10/03)
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
