2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid

Base Information

Chemical Name:2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid
CAS No.:1401695-28-0
Molecular Formula:C₂₈H₂₀N₂O₂S₃
Molecular Weight:512.677
Hs Code.:

Synonyms:2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid

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Chemical Property of 2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid

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Technology Process of 2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid

There total 4 articles about 2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1401695-25-7
5-(4-(diphenylamino)phenyl)-3,4-(ethylenedithio)thiophene-2-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1401695-28-0
2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid

Guidance literature:: With piperidine; In acetonitrile; at 92 ℃; Inert atmosphere;
DOI:10.1002/asia.201100814

Reference yield:

: 158962-92-6
3,4-ethylenedisulfanylthiophene

: 1401695-28-0
2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 75 °C / Inert atmosphere

4.1: piperidine / acetonitrile / 92 °C / Inert atmosphere

With piperidine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki coupling / 4.1: Knoevenagel condensation;
DOI:10.1002/asia.201100814

Reference yield:

: 1196833-22-3
3,4-(ethylenedithio)thiophene-5-carbaldehyde

: 1401695-28-0
2-cyano-3-{5-[4-(diphenylamino)phenyl]-3,4-(ethylenedithio)thiophene-2-yl}acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 75 °C / Inert atmosphere

3: piperidine / acetonitrile / 92 °C / Inert atmosphere

With piperidine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki coupling / 3: Knoevenagel condensation;
DOI:10.1002/asia.201100814