5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

Base Information

Chemical Name:5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate
CAS No.:1388221-49-5
Molecular Formula:C₂₇H₂₀FNO₅
Molecular Weight:457.458
Hs Code.:

Synonyms:5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

Suppliers and Price of 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

There total 7 articles about 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201816-71-8
5-(2-hydroxy-4-methoxybenzoyl)-1-o-tolylphenylpyridin-2(1H)-one

: 403-43-0
4-fluorobenzoyl chloride

: 1388221-49-5
5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2013.06.046

Reference yield:

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 1388221-49-5
5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium / diethyl ether / 0 °C

2: acetic acid; hydrogenchloride / water / 0.5 h / 100 °C

3: methanol / Reflux

4: iodine / dichloromethane

5: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate / water; tetrahydrofuran / 100 °C

6: methanol / Reflux

7: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 5: |Heck Reaction;
DOI:10.1016/j.ejmech.2013.06.046

Reference yield:

: 94719-81-0
ω-formyl-4'-methoxy-2'-hydroxyacetophenone

: 1388221-49-5
5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-fluorobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; hydrogenchloride / water / 0.5 h / 100 °C

2: methanol / Reflux

3: iodine / dichloromethane

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate / water; tetrahydrofuran / 100 °C

5: methanol / Reflux

6: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; 4: |Heck Reaction;
DOI:10.1016/j.ejmech.2013.06.046