N-[6-(diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide

Base Information

• Chemical Name: N-[6-(diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide
• CAS No.: 92104-52-4
• Molecular Formula: C13H17 N5 O4
• Molecular Weight: 307.309
• Mol file: 92104-52-4.mol

Synonyms:6-Pteridinecarboxaldehyde,2-acetamido-4-hydroxy-, diethyl acetal (6CI,7CI); NSC 127924

Chemical Property of N-[6-(diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.44g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[6-(diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide

There total 4 articles about N-[6-(diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,3-triethoxypropene (5444-80-4) → N-(6-diethoxymethyl-4-oxo-3,4-dihydro-pteridin-2-yl)-acetamide (92104-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether; bromine / anschliessend Behandeln mit Natriumhydrogencarbonat enthaltendem wss.Dioxan

2: aqueous NaHCO₃ / Behandeln des Reaktionsgemisches mit wss.H₂O₂

With diethyl ether; bromine; sodium hydrogencarbonate;

DOI:10.1021/ja01628a085

Reference yield:

3,3-diethoxy-2-bromo-propionaldehyde (28621-39-8) → N-(6-diethoxymethyl-4-oxo-3,4-dihydro-pteridin-2-yl)-acetamide (92104-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaHCO₃ / Behandeln des Reaktionsgemisches mit wss.H₂O₂

With sodium hydrogencarbonate;

DOI:10.1021/ja01628a085

Reference yield:

2-amino-6-diethoxymethyl-3H-pteridin-4-one (4227-30-9) + acetic anhydride (108-24-7) → N-(6-diethoxymethyl-4-oxo-3,4-dihydro-pteridin-2-yl)-acetamide (92104-52-4)

Guidance literature:

DOI:10.1021/ja01628a085

upstream raw materials:

2-amino-6-diethoxymethyl-3H-pteridin-4-one

acetic anhydride

1,3,3-triethoxypropene

3,3-diethoxy-2-bromo-propionaldehyde

Downstream raw materials:

folic acid

N⁽²⁾-acetylfolic acid

N-{4-[(2-acetylamino-4-oxo-3,4-dihydro-pteridin-6-ylmethylen)-amino]-benzoyl}-L-glutamic acid

N-(N²-acetyl-10-formyl-pteroyl)-L-glutamic acid