2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

Base Information

Chemical Name:2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide
CAS No.:1186376-03-3
Molecular Formula:C₂₄H₁₄Cl₂N₄O₃
Molecular Weight:477.306
Hs Code.:

Synonyms:2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

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Chemical Property of 2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

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Technology Process of 2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

There total 5 articles about 2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1186375-59-6
1-(4-amino-phenoxy)-5H-benzo[c][1,8]naphthyridin-6-one

: 78686-87-0
2,5-dichloronicotinoyl chloride

: 1186376-03-3
2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 417721-69-8
4-chloro-3-iodopyridin-2-ylamine

: 1186376-03-3
2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / 1,4-dioxane; water / 100 °C

2: potassium carbonate / DMF (N,N-dimethylformamide) / 100 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; DMF (N,N-dimethylformamide); water;

Reference yield:

: 374538-03-1
2-methoxycarbonylphenylboronic acid

: 1186376-03-3
2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / 1,4-dioxane; water / 100 °C

2: potassium carbonate / DMF (N,N-dimethylformamide) / 100 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; DMF (N,N-dimethylformamide); water;