78686-87-0

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Dichloropyridine-3-carbonyl chloride is used as a key intermediate for the synthesis of various pharmaceuticals. Its reactivity allows for the efficient formation of complex molecular structures, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-Dichloropyridine-3-carbonyl chloride is utilized as a crucial component in the production of agrochemicals. Its ability to form stable bonds with other molecules aids in the creation of effective pesticides and herbicides that enhance crop protection and yield.
Used in Fine Chemicals Industry:
2,5-Dichloropyridine-3-carbonyl chloride is employed as a reagent in the synthesis of fine chemicals, including specialty chemicals and advanced materials. Its versatility in forming carbon-carbon and carbon-heteroatom bonds enables the production of high-quality chemicals with specific properties for various applications.
Used in Research and Development:
2,5-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE is also used as a valuable building block in research and development for creating novel molecular structures. Its potential in synthetic organic chemistry facilitates the exploration of new chemical pathways and the discovery of innovative compounds with unique properties and applications.

InChI:InChI=1/C6H2Cl3NO/c7-3-1-4(6(9)11)5(8)10-2-3/h1-2H

Upstream product

• 38076-80-1 5-chloro-2-hydroxypyridine-3-carboxylic acid 

Downstream Products

• 1186376-03-3 2,5-dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide 
• 75291-86-0 2,5-dichloropyridine-3-carboxamide 
• 952152-77-1 (S)-N-((3-(3,5-difluoro-4-(2-chloro-10-oxo-5,6,8,9-tetrahydro-10H-4,4b,7,9a-tetraazabenzo[a]azulen-7-yl)-phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide 
• 1265635-32-2 2,5-dichloro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)nicotinamide 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems

Novel AT1 receptor antagonists bearing the pyrazolo[3,4-b] pyridine bicyclic heteroaromatic system (or structurally related moieties) were designed and synthesized as the final step of a large program devoted to the development of new antihypertensive agents and to the understanding of the molecular basis of their pharmacodynamic and pharmacokinetic properties. The preliminary pharmacological characterization revealed nanomolar AT1 receptor affinity for several compounds of the series and a potent antagonistic activity in isolated rabbit aortic strip functional assay for 7c and 8a. These results stimulated the study of the biopharmaceutical properties of some selected compounds, which were found to be characterized by a permeability from medium to high. Remarkably, the least permeable 7c showed both permeability and oral bioavailability (80%) higher than losartan, but its terminal half-life was shorter. These results suggest that the permeability is not a limiting factor in the pharmacokinetics of these AT1 receptor antagonists.

2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists

A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR'-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R') on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R' = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.