methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate

Base Information

• Chemical Name: methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate
• CAS No.: 364364-49-8
• Molecular Formula: C₁₈H₁₈ClNO₄S
• Molecular Weight: 379.864

Synonyms:methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate

Chemical Property of methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate

Chemical Property:

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Technology Process of methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate

There total 2 articles about methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

toluene-4-sulfonamide (70-55-3) + m-Chlorobenzaldehyde (587-04-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate (364364-49-8)

Guidance literature:

With 4 Angstroem MS; 3-quinuclidinol; titanium(IV) isopropylate; In isopropyl alcohol; at 20 ℃; for 6h;

DOI:10.1021/jo0163952

Reference yield: 58.0%

toluene-4-sulfonamide (70-55-3) + m-Chlorobenzaldehyde (587-04-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate (364364-56-7) + methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate (364364-49-8)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; lanthanum(lll) triflate; In isopropyl alcohol; at 20 ℃; for 24h;

DOI:10.1021/jo0158635

Reference yield:

allyl bromide (106-95-6) + methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(3-chlorophenyl)propionate (364364-49-8) → methyl-2-{[(N-allyl-4-methylphenyl)sulfonamido](3-chlorophenyl)methyl}acrylate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2004.02.100

upstream raw materials:

toluene-4-sulfonamide

m-Chlorobenzaldehyde

acrylic acid methyl ester

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