2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

Base Information

Chemical Name:2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter
CAS No.:166194-07-6
Molecular Formula:C₅₃H₆₅NO₄S₂Si₂
Molecular Weight:900.406
Hs Code.:

2-<N-(tolylsulfonyl)-N-<4-<(tert-butyldiphenylsilyl)oxy>butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

Synonyms:2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

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Chemical Property of 2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

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Technology Process of 2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

There total 8 articles about 2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 108-98-5
thiophenol

: 166193-92-6
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

: 166194-07-6
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00014a023

Reference yield:

: 130372-07-5
4-(tret-butyldiphenylsilyloxy)butan-1-ol

: 166194-07-6
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / triphenoxymethylphosphonium iodide / CH₂Cl₂ / -68 - 20 °C

2: 1.) KH, 2.) 18-crown-6 / 1.) THF, 2.) THF, a) RT, overnight, b) 50 deg C, 6 h

3: 87 percent / TsOH / CH₂Cl₂; methanol / Ambient temperature

4: 84 percent / I₂, Ph₃P, imidazole / CH₂Cl₂ / Ambient temperature

5: 70 percent / DBU / tetrahydrofuran / Ambient temperature

With 1H-imidazole; 18-crown-6 ether; methyltriphenoxyphosphonium iodide; iodine; potassium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00014a023

Reference yield:

: 149365-02-6
4-[(tert-butyldiphenylsilyl)oxy]-1-iodobutane

: 166194-07-6
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>butyl phenyl thioeter

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, 2.) THF, a) RT, overnight, b) 50 deg C, 6 h

2: 87 percent / TsOH / CH₂Cl₂; methanol / Ambient temperature

3: 84 percent / I₂, Ph₃P, imidazole / CH₂Cl₂ / Ambient temperature

4: 70 percent / DBU / tetrahydrofuran / Ambient temperature

With 1H-imidazole; 18-crown-6 ether; iodine; potassium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00014a023