N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide

Base Information

Chemical Name:N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide
CAS No.:88048-42-4
Molecular Formula:C₂₁H₁₈N₂O₄
Molecular Weight:362.385
Hs Code.:

Synonyms:N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide

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Technology Process of N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide

There total 5 articles about N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 88048-26-4
5,6-methylenedioxyindole-3-glyoxyl chloride

: 13324-66-8
N-benzylcyclopropanamine

: 88048-42-4
N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; at -30 - -15 ℃; for 0.25h;
DOI:10.1002/jhet.5570200438

Reference yield:

: 15794-43-1
6,β-dinitro-3,4-methylenedioxystyrene

: 88048-42-4
N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / H₂ / 10percent Pd/C / ethanol; acetic acid; ethyl acetate / 0.75 h / 2068.6 - 2844.3 Torr

2: diethyl ether / 0.5 h / 0 °C

3: 37 percent / diisopropylethylamine / tetrahydrofuran; diethyl ether / 0.25 h / -30 - -15 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; acetic acid; ethyl acetate;
DOI:10.1002/jhet.5570200438

Reference yield:

: 100-39-0
benzyl bromide

: 88048-42-4
N-Benzyl-N-cyclopropyl-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH / 1) DMF

2: 77 percent / H₂, conc. aq. HCl / 5percent Pd/C / ethanol / 12 h / 760 Torr

3: 37 percent / diisopropylethylamine / tetrahydrofuran; diethyl ether / 0.25 h / -30 - -15 °C

With hydrogenchloride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1002/jhet.5570200438