3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester
• CAS No.: 438620-52-1
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.418
• Mol file: 438620-52-1.mol

Synonyms:3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester

Chemical Property of 3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester

There total 3 articles about 3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2S-(o-phenylbenzoyl)amino-3S-hydroxybutylic acid methyl ester (438620-50-9) + 2,2-dimethoxy-propane (77-76-9) → 3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester (438620-52-1)

Guidance literature:

toluene-4-sulfonic acid; In chloroform; benzene;

DOI:10.1021/ol025865r

Reference yield:

2S-(o-phenylbenzoyl)amino-3S-hydroxybutylic acid (438620-49-6) → 3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester (438620-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / K₂CO₃ / dimethylformamide

2: 40 percent / p-TsOH / benzene; CHCl₃

With potassium carbonate; toluene-4-sulfonic acid; In chloroform; N,N-dimethyl-formamide; benzene;

DOI:10.1021/ol025865r

Reference yield:

o-phenylbenzoyl chloride (14002-52-9) → 3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid methyl ester (438620-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / NaOH

2: 60 percent / K₂CO₃ / dimethylformamide

3: 40 percent / p-TsOH / benzene; CHCl₃

With sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; In chloroform; N,N-dimethyl-formamide; benzene;

DOI:10.1021/ol025865r

upstream raw materials:

2S-(o-phenylbenzoyl)amino-3S-hydroxybutylic acid methyl ester

2,2-dimethoxy-propane

2S-(o-phenylbenzoyl)amino-3S-hydroxybutylic acid

o-phenylbenzoyl chloride

Downstream raw materials:

3-(o-phenylbenzoyl)-2,2,5S-trimethyloxazolidine-4S-carboxylic acid