1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide

Base Information

Chemical Name:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide
CAS No.:1295298-36-0
Molecular Formula:C₂₃H₁₆F₄N₄O
Molecular Weight:440.4
Hs Code.:

Synonyms:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide

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Chemical Property of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide

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Technology Process of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide

There total 4 articles about 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220165-92-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

: 1108698-58-3
1-(3-(trifluoromethyl)phenyl)cyclopropane-1-amine hydrochloride

: 1295298-36-0
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide

Guidance literature:: 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1.66667h;

1-(3-(trifluoromethyl)phenyl)cyclopropane-1-amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 1295298-36-0
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

1.2: 20 - 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -20 - -10 °C

2.3: 22 - 55 °C / pH 6 - 7

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.67 h / 20 °C

3.2: 15 h / 20 °C

With oxalyl dichloride; isopropylmagnesium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 70201-42-2
3,5-dibromopyridine-4-carboxaldehyde

: 1295298-36-0
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

1.2: 20 - 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -20 - -10 °C

2.3: 22 - 55 °C / pH 6 - 7

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.67 h / 20 °C

3.2: 15 h / 20 °C

With oxalyl dichloride; isopropylmagnesium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;