2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

Base Information

• Chemical Name: 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one
• CAS No.: 1253731-85-9
• Molecular Formula: C₂₅H₂₅N₃O₅
• Molecular Weight: 447.491
• Mol file: 1253731-85-9.mol

Synonyms:2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

Chemical Property of 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

There total 8 articles about 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one (1253731-87-1) → 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one (1253731-85-9)

Guidance literature:

5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one; With sulfuric acid; acetic acid; In water; at 75 ℃; for 5h;

With sodium carbonate; In methanol; pH=8;

Reference yield:

2-amino-4,6-difluoro-benzamide (893428-66-5) → 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one (1253731-85-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere

2: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 63 h / 20 - 95 °C / Inert atmosphere

4: acetic acid; sulfuric acid / water / 5 h / 75 °C

With sodium hydrogen sulfate; sulfuric acid; sodium methylate; sodium hydride; toluene-4-sulfonic acid; acetic acid; In N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-amino-4,6-difluorobenzoic acid (126674-77-9) → 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one (1253731-85-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 1 h / 20 °C

1.2: 6 h / 20 °C

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere

3.1: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 63 h / 20 - 95 °C / Inert atmosphere

5.1: acetic acid; sulfuric acid / water / 5 h / 75 °C

With sodium hydrogen sulfate; sulfuric acid; sodium methylate; sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

2-amino-4,6-difluoro-benzamide

2-amino-4,6-difluorobenzoic acid

4-(methoxymethoxy)-3,5-dimethylbenzaldehyde