5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

Base Information

Chemical Name:5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one
CAS No.:1253731-87-1
Molecular Formula:C₂₇H₂₉N₃O₆
Molecular Weight:491.544
Hs Code.:

Synonyms:5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

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Chemical Property of 5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

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Technology Process of 5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

There total 7 articles about 5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1253731-86-0
2-(pyridin-3-ylmethoxy)ethanol

: 1253731-84-8
7-fluoro-5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

: 1253731-87-1
5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 95 ℃; for 63h; Inert atmosphere;

Reference yield:

: 893428-66-5
2-amino-4,6-difluoro-benzamide

: 1253731-87-1
5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere

2: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 63 h / 20 - 95 °C / Inert atmosphere

With sodium hydrogen sulfate; sodium methylate; sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 126674-77-9
2-amino-4,6-difluorobenzoic acid

: 1253731-87-1
5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 1 h / 20 °C

1.2: 6 h / 20 °C

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere

3.1: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 63 h / 20 - 95 °C / Inert atmosphere

With sodium hydrogen sulfate; sodium methylate; sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;