dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate

Base Information

• Chemical Name: dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate
• CAS No.: 1270043-91-8
• Molecular Formula: C₁₇H₂₆O₅Si
• Molecular Weight: 338.476
• Mol file: 1270043-91-8.mol

Synonyms:dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate

Chemical Property of dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate

There total 1 articles about dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trans-3,5-dimethoxy-4-hydroxycinnamic acid (530-59-6,7362-37-0) + tert-butyldimethylsilyl chloride (18162-48-6) → dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate (1270043-91-8)

Guidance literature:

trans-3,5-dimethoxy-4-hydroxycinnamic acid; With 1H-imidazole; In N,N-dimethyl-formamide;

tert-butyldimethylsilyl chloride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

With potassium carbonate; In tetrahydrofuran; methanol; water;

Reference yield: 90.4%

dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate (1270043-91-8) + isopropyl alcohol (67-63-0,8013-70-5) → C20H32O5Si

Guidance literature:

With dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/ja5059026

Reference yield: 85.8%

(S)-Methyl lactate (27871-49-4,2155-30-8) + dimethyl (2S,2E)-2-((3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)succinate (1270043-91-8) → (S)-1-methoxy-1-oxopropan-2-yl (E)-3-(4-((tertbutyldimethylsilyl)oxy)-3,5-dimethoxyphenyl)acrylate

Guidance literature:

With dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/ja5059026

upstream raw materials:

trans-3,5-dimethoxy-4-hydroxycinnamic acid

tert-butyldimethylsilyl chloride