Technology Process of ethyl 6-{[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1-benzothiophene-2-carboxylate
There total 13 articles about ethyl 6-{[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1-benzothiophene-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methoxycarbonylsulfamoyl-triethylammmonium hydroxide;
In
tetrahydrofuran;
at 100 ℃;
for 0.166667h;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / 1,2-dichloro-ethane / 2.5 h / 80 °C
2.1: sodium hydride / tetrahydrofuran / 0.17 h
2.2: 18 h / Heating / reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 - 75 °C / sealed tube
4.1: thiourea / ethanol; water / 7 h / Heating / reflux
5.1: sodium hydride / dimethyl sulfoxide / 0.25 h
6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
7.1: water / 0.01 h / 210 °C / microwave irradiation
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C
9.1: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / 0.17 h / 100 °C / microwave irradiation
With
methoxycarbonylsulfamoyl-triethylammmonium hydroxide; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea; orthoformic acid triethyl ester; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thiourea / ethanol; water / 7 h / Heating / reflux
2: sodium hydride / dimethyl sulfoxide / 0.25 h
3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4: water / 0.01 h / 210 °C / microwave irradiation
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C
6: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / 0.17 h / 100 °C / microwave irradiation
With
methoxycarbonylsulfamoyl-triethylammmonium hydroxide; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;