Multi-step reaction with 8 steps
1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / 1,2-dichloro-ethane / 2.5 h / 80 °C
2.1: sodium hydride / tetrahydrofuran / 0.17 h
2.2: 18 h / Heating / reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 - 75 °C / sealed tube
4.1: thiourea / ethanol; water / 7 h / Heating / reflux
5.1: sodium hydride / dimethyl sulfoxide / 0.25 h
6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
7.1: water / 0.01 h / 210 °C / microwave irradiation
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C
With
water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea; orthoformic acid triethyl ester; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;