1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Base Information

Chemical Name:1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole
CAS No.:1038988-08-7
Molecular Formula:C₂₀H₂₂BrN₃O₂S
Molecular Weight:448.384
Hs Code.:

Synonyms:1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

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Chemical Property of 1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Chemical Property:

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Technology Process of 1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

There total 7 articles about 1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1038988-57-6
4-(4-methylpiperazine-1-yl methyl)-1H-indole

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1038988-08-7
1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Guidance literature:: 4-(4-methylpiperazine-1-yl methyl)-1H-indole; With sodium hydride; at 10 - 25 ℃; Inert atmosphere;

4-bromobenzenesulfonyl chloride; at 10 - 25 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.10.057

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1038988-08-7
1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 3 h / Reflux

1.2: 0.5 h / 10 - 25 °C

2.1: N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

3.1: hydrazine hydrate / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 68 °C / Inert atmosphere

5.1: sodium hydride / 10 - 25 °C / Inert atmosphere

5.2: 10 - 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; hydrazine hydrate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.057

Reference yield:

: 349395-92-2
(2-methyl-3-nitrophenyl)(4-methylpiperazin-1-yl)methanone

: 1038988-08-7
1-(4-bromobenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

2.1: hydrazine hydrate / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 68 °C / Inert atmosphere

4.1: sodium hydride / 10 - 25 °C / Inert atmosphere

4.2: 10 - 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; hydrazine hydrate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.057