2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Base Information

Chemical Name:2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
CAS No.:1299487-22-1
Molecular Formula:C₂₀H₂₀F₆N₂O₂
Molecular Weight:434.381
Hs Code.:

Synonyms:2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

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Chemical Property of 2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

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Technology Process of 2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

There total 3 articles about 2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299487-23-2
1,1,1,3,3,3-hexafluoro-2-(4-((3-(4-nitrophenoxy)pyrrolidin-1-yl)methyl)phenyl)propan-2-ol

: 1299487-22-1
2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 1h; under 2250.23 Torr;

Reference yield:

: 405887-36-7,1233860-29-1,218944-23-1
1,1-dimethylethyl 3-(S)-(4-nitrophenoxy)-1-pyrrolidine-carboxylate

: 1299487-22-1
2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: potassium carbonate / acetonitrile / 1 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 2250.23 Torr

With hydrogen; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1187930-72-8,218944-24-2
3-(S)-(4-nitrophenoxy)pyrrolidine

: 1299487-22-1
2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 2250.23 Torr

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In ethanol; acetonitrile;