1N-Boc 3-(4'-nitrophenoxy) pyrrolidine

Base Information

• Chemical Name: 1N-Boc 3-(4'-nitrophenoxy) pyrrolidine
• CAS No.: 405887-36-7
• Molecular Formula: C15H20N2O5
• Molecular Weight: 308.334
• Hs Code.: 2933990090
• Mol file: 405887-36-7.mol

Synonyms:1-(tert-Butoxycarbonyl)-3-(4-nitrophenoxy)pyrrolidine;tert-Butyl 3-(4-nitrophenoxy)pyrrolidine-1-carboxylate;3-(4-Nitro-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 1N-Boc 3-(4'-nitrophenoxy) pyrrolidine

Chemical Property:

• Boiling Point: 440.172 °C at 760 mmHg
• Flash Point: 220.008 °C
• PSA: 84.59000
• Density: 1.242 g/cm³
• LogP: 3.44410
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Nitro-phenoxy)-pyrrolidine-1-carboxy acid tert-butyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1N-Boc 3-(4'-nitrophenoxy) pyrrolidine

There total 1 articles about 1N-Boc 3-(4'-nitrophenoxy) pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 1,1-dimethylethyl 3-(S)-(4-nitrophenoxy)-1-pyrrolidine-carboxylate (405887-36-7,1233860-29-1,218944-23-1)

Guidance literature:

Reference yield:

1,1-dimethylethyl 3-(S)-(4-nitrophenoxy)-1-pyrrolidine-carboxylate (405887-36-7,1233860-29-1,218944-23-1) → 3-(S)-(4-nitrophenoxy)pyrrolidine (1187930-72-8,218944-24-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

1,1-dimethylethyl 3-(S)-(4-nitrophenoxy)-1-pyrrolidine-carboxylate (405887-36-7,1233860-29-1,218944-23-1) → 1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yloxy)phenyl)urea (1299487-21-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: potassium carbonate / acetonitrile / 1 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 2250.23 Torr

4.1: tetrahydrofuran / 0.5 h / 20 °C

4.2: 20 °C

With hydrogen; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Downstream raw materials:

3-(S)-(4-nitrophenoxy)pyrrolidine

1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yloxy)phenyl)urea

2-(4-((3-(4-aminophenoxy)pyrrolidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

1,1,1,3,3,3-hexafluoro-2-(4-((3-(4-nitrophenoxy)pyrrolidin-1-yl)methyl)phenyl)propan-2-ol