2-(4-chlorophenyl)-3-phenylbutanedinitrile

Base Information

• Chemical Name: 2-(4-chlorophenyl)-3-phenylbutanedinitrile
• CAS No.: 7497-44-1
• Molecular Formula: C16H11 Cl N2
• Molecular Weight: 266.73
• Mol file: 7497-44-1.mol

Synonyms:Succinonitrile,2-(p-chlorophenyl)-3-phenyl- (6CI,7CI); NSC 405172

Chemical Property of 2-(4-chlorophenyl)-3-phenylbutanedinitrile

Chemical Property:

• Vapor Pressure: 1.07E-07mmHg at 25°C
• Boiling Point: 432.9°Cat760mmHg
• Flash Point: 182.2°C
• Density: 1.233g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-chlorophenyl)-3-phenylbutanedinitrile

There total 7 articles about 2-(4-chlorophenyl)-3-phenylbutanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

sodium cyanide (773837-37-9) + α-(p-chlorophenyl)-β-phenylacrylonitrile (6269-09-6,16610-81-4,3695-93-0) → 2-(4-chlorophenyl)-3-phenylsuccinonitrile (7497-44-1)

Guidance literature:

With ammonium chloride; In water; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1055/s-0032-1317351

Reference yield: 86.0%

potassium cyanide + α-(p-chlorophenyl)-β-phenylacrylonitrile (6269-09-6,16610-81-4,3695-93-0) → 2-(4-chlorophenyl)-3-phenylsuccinonitrile (7497-44-1)

Guidance literature:

With water; ammonium chloride; In N,N-dimethyl-formamide; for 6h; Heating;

DOI:10.3184/174751917X15105690662863

Reference yield:

benzaldehyde (100-52-7) + p-chlorobenzyl cyanide (140-53-4) → (+/-)-erythro-2-(4-chloro-phenyl)-3-phenyl-succinonitrile (7497-44-1)

Guidance literature:

With methanol; sodium cyanide;

DOI:10.1021/ja01540a061

upstream raw materials:

benzaldehyde

sodium cyanide

α-(p-chlorophenyl)-β-phenylacrylonitrile

p-chlorobenzyl cyanide

Downstream raw materials:

3-(4-chlorophenyl)-4-phenyl-1H-pyrrole

(+/-)-erythro-3-phenyl-2-(4-chloro-phenyl)-succinic acid diamide

(+/-)-erythro-2-(4-chloro-phenyl)-3-phenyl-succinic acid