1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Base Information

Chemical Name:1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea
CAS No.:1443245-38-2
Molecular Formula:C₃₇H₄₃ClN₈O₂
Molecular Weight:667.254
Hs Code.:

1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Synonyms:1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

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Chemical Property of 1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

There total 17 articles about 1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443245-36-0
1-[5-tert-butyl-2-(3-hydroxymethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

: 124-63-0
methanesulfonyl chloride

: 1443245-37-1
methanesulfonic acid 3-[3-tert-butyl-5-(3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-ureido)-pyrazol-1-yl]-benzyl ester

: 1443245-38-2
1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 725685-92-7
3-(5-amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid ethyl ester

: 1443245-37-1
methanesulfonic acid 3-[3-tert-butyl-5-(3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-ureido)-pyrazol-1-yl]-benzyl ester

: 1443245-38-2
1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; triethylamine / ethanol / 44.5 h / 20 °C

2: sodium hydroxide / water; ethyl acetate / 1.25 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 100 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

With sodium tetrahydroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 38235-71-1
3-hydrazinobenzoic acid

: 1443245-37-1
methanesulfonic acid 3-[3-tert-butyl-5-(3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-ureido)-pyrazol-1-yl]-benzyl ester

: 1443245-38-2
1-[5-tert-butyl-2-(3-chloromethyl-phenyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 19 h / Reflux

2: sodium tetrahydroborate; triethylamine / ethanol / 44.5 h / 20 °C

3: sodium hydroxide / water; ethyl acetate / 1.25 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 100 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

With sodium tetrahydroborate; sulfuric acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;