(R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol

Base Information

Chemical Name:(R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol
CAS No.:203913-53-5
Molecular Formula:C₁₇H₂₅IO₄
Molecular Weight:420.288
Hs Code.:

Synonyms:(R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol

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Chemical Property of (R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol

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Technology Process of (R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol

There total 7 articles about (R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 203913-50-2
(E)-5-[(4R,5R)-5-(3-Benzyloxy-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-pent-2-en-1-ol

: 203913-53-5
(R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol

Guidance literature:: With iodonium di(2,4,6-trimethylpyridine) perchlorate; In water; acetonitrile; for 0.0833333h; Ambient temperature;
DOI:10.1021/jo961367i

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 203913-53-5
(R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / tetrahydrofuran / 0.5 h

2: 85 percent / Hg(OAc)2 / 18 h / Heating

3: 87 percent / acetonitrile / 0.67 h / 60 °C

4: AD-mix-β, methanesulfonamide / 2-methyl-propan-2-ol; H2O / 72 h / 0 °C

5: 93 percent / (+/-)-10-camphorsulfonic acid / CH₂Cl₂ / 0.5 h

6: 92 percent / diisobutylaluminum hydride / CH₂Cl₂; heptane / 0.5 h / -40 °C

7: 91 percent / iodonium dicollidine perchlorate / H₂O; acetonitrile / 0.08 h / Ambient temperature

With methanesulfonamide; iodonium di(2,4,6-trimethylpyridine) perchlorate; AD-mix-β; camphor-10-sulfonic acid; mercury(II) diacetate; diisobutylaluminium hydride; In tetrahydrofuran; n-heptane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo961367i

Reference yield:

: 126260-80-8
(3RS)-6-benzyloxyhex-1-en-3-ol

: 203913-53-5
(R)-4-Benzyloxy-1-[(2R,5R)-5-((S)-2-hydroxy-1-iodo-ethyl)-tetrahydro-furan-2-yl]-butan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / Hg(OAc)2 / 18 h / Heating

2: 87 percent / acetonitrile / 0.67 h / 60 °C

3: AD-mix-β, methanesulfonamide / 2-methyl-propan-2-ol; H2O / 72 h / 0 °C

4: 93 percent / (+/-)-10-camphorsulfonic acid / CH₂Cl₂ / 0.5 h

5: 92 percent / diisobutylaluminum hydride / CH₂Cl₂; heptane / 0.5 h / -40 °C

6: 91 percent / iodonium dicollidine perchlorate / H₂O; acetonitrile / 0.08 h / Ambient temperature

With methanesulfonamide; iodonium di(2,4,6-trimethylpyridine) perchlorate; AD-mix-β; camphor-10-sulfonic acid; mercury(II) diacetate; diisobutylaluminium hydride; In n-heptane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo961367i