7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Base Information

Chemical Name:7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one
CAS No.:1427015-09-5
Molecular Formula:C₃₀H₃₅BrO₅
Molecular Weight:555.509
Hs Code.:

Synonyms:7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

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Chemical Property of 7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

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Technology Process of 7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

There total 6 articles about 7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1427015-07-3
3-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)propanal

: 89201-84-3
4-(4-bromophenyl)-2-butanone

: 1427015-09-5
7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Guidance literature:: 4-(4-bromophenyl)-2-butanone; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

3-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)propanal; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jo302723n

Reference yield:

: 1427015-03-9
3-(benzyloxy)-5-isopropoxy-4-methoxybenzaldehyde

: 1427015-09-5
7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: 24.5 h / 80 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 2.5 h / -78 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jo302723n

Reference yield:

: 1427015-00-6
methyl 3-(benzyloxy)-5-isopropoxy-4-methoxybenzoate

: 1427015-09-5
7-(3-(benzyloxy)-5-isopropoxy-4-methoxyphenyl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.17 h / -78 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

3.3: 24.5 h / 80 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

5.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

5.2: 2.5 h / -78 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil; 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jo302723n