6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine

Base Information

• Chemical Name: 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine
• CAS No.: 102997-86-4
• Molecular Formula: C₅₀H₄₅N₅O₅
• Molecular Weight: 795.938

Synonyms:6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine

Chemical Property of 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine

Chemical Property:

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Technology Process of 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine

There total 3 articles about 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

6-N-5'-O-Bis<4-methoxytriphenylmethyl>-2',3'-lyxo-anhydroadenosine (102997-84-2) → 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine (102997-86-4) + 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-3'-deoxy-β-D-threo-pentofuranosyl>-adenine (102997-85-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1055/s-1986-31509

Reference yield:

9-(2',3'-O-anhydro-β-D-lyxofuranosyl)adenine (40110-98-3) → 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine (102997-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / pyridine / 20 h / 60 °C

2: 17 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1055/s-1986-31509

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 6-N-(4-Methoxytriphenylmethyl)-9-<5'-O-(4-methoxytriphenylmethyl)-2'-deoxy-β-D-threo-pentofuranosyl>-adenine (102997-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / pyridine / 20 h / 60 °C

2: 17 percent / LiAlH₄ / tetrahydrofuran / 3 h / 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1055/s-1986-31509

upstream raw materials:

6-N-5'-O-Bis<4-methoxytriphenylmethyl>-2',3'-lyxo-anhydroadenosine

9-(2',3'-O-anhydro-β-D-lyxofuranosyl)adenine

mono-4-methoxytrityl chloride

Downstream raw materials:

9-(2'-deoxy-β-D-threo-ribofuranosyl)-adenine

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