tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate
CAS No.:1567346-27-3
Molecular Formula:C₂₇H₃₅N₇O₇S
Molecular Weight:601.684
Hs Code.:

tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

Synonyms:tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

There total 3 articles about tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1567346-26-2
3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

: 1567346-27-3
tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.12.122

Reference yield:

: 1448312-88-6
tert-butyl 4-(2-(3-bromo-5-(2-(tert-butoxycarbonylamino)-acetamido)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

: 1567346-27-3
tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

2: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 1 h / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dihydrogen peroxide; potassium acetate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.122

Reference yield:

: C₃₃H₄₆BN₇O₈S

: 1567346-27-3
tert-butyl 4-(2-(3-(2-(tert-butoxycarbonylamino)acetamido)-5-hydroxyphenyl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride

2: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 1 h / 0 °C

With hydrogenchloride; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2013.12.122