3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

Base Information

Chemical Name:3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid
CAS No.:1567346-26-2
Molecular Formula:C₂₇H₃₆BN₇O₈S
Molecular Weight:629.502
Hs Code.:

3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

Synonyms:3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

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Chemical Property of 3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

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Technology Process of 3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

There total 3 articles about 3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448312-88-6
tert-butyl 4-(2-(3-bromo-5-(2-(tert-butoxycarbonylamino)-acetamido)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

: 73183-34-3
bis(pinacol)diborane

: 1567346-26-2
3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

: C₃₃H₄₆BN₇O₈S

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.bmcl.2013.12.122

Reference yield:

: 1448312-88-6
tert-butyl 4-(2-(3-bromo-5-(2-(tert-butoxycarbonylamino)-acetamido)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

: 1567346-26-2
3-(5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-5-(2-(tert-butoxycarbonylamino)acetamido)phenylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

2: hydrogenchloride

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.122