1,2-Diaminopropane

Base Information

• Chemical Name: 1,2-Diaminopropane
• CAS No.: 78-90-0
• Deprecated CAS: 10424-38-1,68928-99-4
• Molecular Formula: C₃H₁₀N₂
• Molecular Weight: 74.1258
• Hs Code.: 29212900
• European Community (EC) Number: 201-155-9
• ICSC Number: 0942
• NSC Number: 175731
• UN Number: 2258
• UNII: 2A4P522UGO
• DSSTox Substance ID: DTXSID4021761
• Nikkaji Number: J4.225K
• Wikipedia: 1,2-Diaminopropane
• Wikidata: Q161461
• Metabolomics Workbench ID: 42223
• ChEMBL ID: CHEMBL1319459
• Mol file: 78-90-0.mol

Synonyms:1,2-diaminopropane;1,2-diaminopropane acetate;1,2-diaminopropane diacetate;1,2-diaminopropane dihydrochloride, (R)-isomer;1,2-diaminopropane dihydrochloride, (S)-isomer;1,2-diaminopropane, (R)-isomer;1,2-diaminopropane, (S)-isomer

Chemical Property of 1,2-Diaminopropane

Chemical Property:

• Appearance/Colour: A colorless liquid with an ammonia-like odor.
• Vapor Pressure: 14 mm Hg ( 20 °C)
• Melting Point: -37 °C
• Refractive Index: n20/D 1.446
• Boiling Point: 117.3 °C at 760 mmHg
• PKA: 9.82(at 25℃)
• Flash Point: 33.3 °C
• PSA: 52.04000
• Density: 0.863 g/cm³
• LogP: 0.69290
• Storage Temp.: Flammables area
• Sensitive.: Air Sensitive & Hygroscopic
• Solubility.: H2O: very soluble
• Water Solubility.: SOLUBLE
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 74.084398327
• Heavy Atom Count: 5
• Complexity: 20.9
• Transport DOT Label: Corrosive Flammable Liquid

Purity/Quality:

99% ^*data from raw suppliers

rac1,2-Diaminopropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 10-21/22-35-42/43
• Safety Statements: 26-37/39-45-36/37/39-23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CC(CN)N
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Medical observation is indicated.
• Uses: In conjunction with cupric sulfate it is a very sensitive reagent for mercury. 1,2-Diaminopropane was used as model precursor in the electron induced deposition of amorphous carbon nitride films.

Technology Process of 1,2-Diaminopropane

There total 44 articles about 1,2-Diaminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(E/Z)-1-azido-2-propanone O-methyloxime → 1,2-diaminopropan (78-90-0,10424-38-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Ambient temperature;

Reference yield: 67.16%

1,2-Dichloropropane (26198-63-0,78-87-5) → 1,2-diaminopropan (78-90-0,10424-38-1)

Guidance literature:

With ammonium hydroxide; tetramethlyammonium chloride; copper(II) oxide; at 160 ℃; for 3h; Reagent/catalyst;

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → piperazine (110-85-0) + N-(1-aminomethyl-2-hydroxyethyl)amine (2811-20-3) + 1,2,3-triaminopropane (21291-99-6) + (RS)-2-methylpiperazine (109-07-9) + ethylenediamine (107-15-3,85404-18-8) + 1,2-diaminopropan (78-90-0,10424-38-1) + 3,5-dimethylpiperazine (108-49-6)

Guidance literature:

With ammonia; hydrogen; Raney nickel; In water; at 200 ℃; under 15001.5 - 150015 Torr; Product distribution / selectivity; Autoclave;

upstream raw materials:

1-nitro-2-nitroso-propane

1,2-Dichloropropane

1,2-Dibromopropane

β-nitro-isopropylamine

Downstream raw materials:

(R)-1.2-bis-benzamino-propane

(RS)-2-methylpiperazine

1,2-diaminopropane-N,N,N',N'-tetraacetic acid

4-methyl-N-(1-methyl-2-{[(4-methylphenyl)sulfonyl]amino}ethyl)benzenesulfonamide

Refernces

• 1、 Yue, Chuan-Jun,Di, Kai,Gu, Li-Ping,Zhang, Zhen-Wei,Ding, Lin-Lin. "Selective amination of 1,2-propanediol over Co/La3O4 catalyst prepared by liquid-phase reduction". . . Retrieved 2019/08/20.
• 2、 -. "A phase transfer catalysis process for preparing 1, 2 - propylene diamine method". Paragraph 0017; 0030; 0031. . Retrieved 2017/08/25.