(E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone

Base Information

• Chemical Name: (E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone
• CAS No.: 122567-28-6
• Molecular Formula: C₂₀H₂₂O₂
• Molecular Weight: 294.393
• Mol file: 122567-28-6.mol

Synonyms:(E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone

Chemical Property of (E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone

There total 1 articles about (E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,5,6-tetramethylanisole (14337-37-2) + Cinnamoyl chloride (102-92-1,17082-09-6) → (E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone (122567-28-6)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo00278a011

Reference yield: 68.0%

(E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone (122567-28-6) → (E)-1-(4-Methoxy-2,3,5-trimethyl-6-nitromethyl-phenyl)-3-phenyl-propenone (122567-33-3)

Guidance literature:

With nitric acid; acetic anhydride; at 0 ℃; for 2h;

DOI:10.1021/jo00278a011

Reference yield:

(E)-1-(4-Methoxy-2,3,5,6-tetramethyl-phenyl)-3-phenyl-propenone (122567-28-6) → (3R,4R)-6-Methoxy-5,7,8-trimethyl-4-nitro-3-phenyl-3,4-dihydro-2H-naphthalen-1-one (122567-40-2,122567-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 99percent HNO₃, acetic anhydride / 2 h / 0 °C

2: 28 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / ethanol / 24 h / Heating

With nitric acid; acetic anhydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol;

DOI:10.1021/jo00278a011

upstream raw materials:

2,3,5,6-tetramethylanisole

Cinnamoyl chloride

Downstream raw materials:

(E)-1-(4-Methoxy-2,3,5-trimethyl-6-nitromethyl-phenyl)-3-phenyl-propenone

(3R,4R)-6-Methoxy-5,7,8-trimethyl-4-nitro-3-phenyl-3,4-dihydro-2H-naphthalen-1-one

(3S,4R)-6-Methoxy-5,7,8-trimethyl-4-nitro-3-phenyl-3,4-dihydro-2H-naphthalen-1-one