4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide

Base Information

• Chemical Name: 4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide
• CAS No.: 1444001-60-8
• Molecular Formula: C₁₃H₁₆N₂O₅
• Molecular Weight: 280.28
• Mol file: 1444001-60-8.mol

Synonyms:4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide

Chemical Property of 4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide

There total 2 articles about 4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(1,3-dioxolan-2-yl)-N1-hydroxybenzenecarboximidamide (852691-00-0) + chloroformic acid ethyl ester (541-41-3) → 4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide (1444001-60-8)

Guidance literature:

With triethylamine; In dichloromethane; at -10 - 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2013.03.056

Reference yield:

4-(1,3-dioxolan-2-yl)benzonitrile (66739-89-7) → 4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide (1444001-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; hydroxylamine hydrochloride / ethanol / 15 h / 60 °C

2: triethylamine / dichloromethane / 4 h / -10 - 20 °C

With hydroxylamine hydrochloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2013.03.056

Reference yield: 87.0%

4-(1,3-dioxolan-2-yl)-N'-((ethoxycarbonyl)oxy)benzimidamide (1444001-60-8) → 3-(4-(1,3-dioxolan-2-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one (1444001-61-9)

Guidance literature:

In N,N-dimethyl-formamide; at 140 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.ejmech.2013.03.056

upstream raw materials:

4-(1,3-dioxolan-2-yl)benzonitrile

4-(1,3-dioxolan-2-yl)-N¹-hydroxybenzenecarboximidamide

chloroformic acid ethyl ester

Downstream raw materials:

(R)-ethyl 1-(4-(2-oxo-5-(((4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzyl)amino)methyl)oxazolidin-3-yl)phenyl)piperidine-4-carboxylate

3-(4-(1,3-dioxolan-2-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzaldehyde

(S)-ethyl 1-(4-(2-oxo-5-(((4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzyl)amino)methyl)oxazolidin-3-yl)phenyl)piperidine-4-carboxylate