1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)

Base Information

Chemical Name:1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)
CAS No.:1321964-42-4
Molecular Formula:C₁₅H₁₉F₃N₂O₃
Molecular Weight:332.323
Hs Code.:

Synonyms:1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)

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Chemical Property of 1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)

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Technology Process of 1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)

There total 4 articles about 1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1321963-18-1
2-(2-bromo-4-(trifluoromethoxy)phenyl)-1,3-dioxolane

: 1321964-42-4
1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)

Guidance literature:: 1-methyl-piperazine; 2-(2-bromo-4-(trifluoromethoxy)phenyl)-1,3-dioxolane; With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 0.333333h; Inert atmosphere;

With palladium diacetate; In 1,4-dioxane; at 90 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm1010644

Reference yield:

: 883546-30-3
2-bromo-1-iodo-4-(trifluoromethoxy)benzene

: 1321964-42-4
1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile / 0.5 h / Inert atmosphere

1.2: 16 h / 95 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: sodium periodate; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 16 h / 0 - 20 °C

3.1: toluene-4-sulfonic acid / benzene / 8 h / 20 °C / Reflux

4.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.33 h / Inert atmosphere

4.2: 8 h / 90 °C / Inert atmosphere

With sodium periodate; osmium(VIII) oxide; caesium carbonate; toluene-4-sulfonic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jm1010644

Reference yield:

: 1321963-17-0
(E)-2-bromo-1-styryl-4-(trifluoromethoxy)benzene

: 1321964-42-4
1-(2-(1,3-dioxolan-2-yl)-5-(trifluoromethoxyphenyl)-4-methylpiperazine)

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium periodate; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 16 h / 0 - 20 °C

2.1: toluene-4-sulfonic acid / benzene / 8 h / 20 °C / Reflux

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.33 h / Inert atmosphere

3.2: 8 h / 90 °C / Inert atmosphere

With sodium periodate; osmium(VIII) oxide; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/jm1010644